96290-79-8

Upstream product

• 310-71-4 ethoxyflurane 
• 459-72-3 ethyl 2-fluoroacetate 
• 64-17-5 ethanol 
• 359-32-0 chlorofluoroacetyl chloride 
• 359-34-2 chlorofluoroacetyl fluoride 
• 623-73-4 diazoacetic acid ethyl ester 
• 562-85-6 chloro-fluoro-orthoacetic acid triethyl ester 

Downstream Products

• 401-58-1 ethyl 2-fluoro-2-iodoacetate 
• 129600-91-5 ethyl 2-(p-chlorophenylthio)-2-fluoroacetate 
• 39547-73-4 (4-Chloro-benzenesulfonyl)-fluoro-acetic acid ethyl ester 
• 216776-67-9 (5-Cyano-6-methyl-2-phenyl-pyrimidin-4-ylsulfanyl)-fluoro-acetic acid ethyl ester 
• 127500-37-2 2-chloro-2-fluoro-N-(2-phenylethyl)acetamide 
• 216578-83-5 (RS)-N-benzyl-2-chloro-2-fluoroethanamide 
• 459-72-3 ethyl 2-fluoroacetate 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 643-77-6 fluoro-phenyl-acetic acid ethyl ester 
• 130754-17-5 ethyl 2-fluoro-2-(4-fluorophenyl)acetate 
• 74569-27-0 Ethyl 4-chloro-α-fluorophenylacetate 
• 1234908-22-5 ethyl 2-fluoro-2-[4-(trifluoromethyl)phenyl]acetate 
• 128839-58-7 ethyl 2-fluoro-2-(2-methylphenyl)acetate 
• 130754-15-3 ethyl 2-fluoro-2-(3-methoxyphenyl)acetate 

Relevant academic research and scientific papers

REACTION OF ALKYL 2-CHLORO-1,1,2-TRIFLUOROETHYL ETHERS WITH LEWIS ACIDS

Ethyl 2-chloro-1,1,2-trifluoroethyl ether heated with boron trifluoride etherate gave ethyl fluoride and chlorofluoroacetyl fluoride.When heated with aluminium chloride, it afforded a mixture of ethyl fluoride, ethyl chloride, chlorofluoroacetyl fluoride, and chlorofluoroacetyl chloride.Treatment of the acyl halides with ethanol yielded ethyl chlorofluoroacetate.Butyl and octyl 2-chloro-1,1,2-trifluoroethyl ethers gave directly butyl and octyl chlorofluoroacetates, respectively, under similar conditions.

TRANSFORMATION D'OXYDES D'ALKYLES ET DE POLYFLUOROALKYLES PAR LES ACIDES DE LEWIS. INFLUENCE DES RADICAUX ALKYLES.

The generation of perfluoroalkanoyl fluorides from perfluoroalkyl ethers by Lewis acids RHOCF2RF -> FRH + RFCOF depends mainly upon the nature of the alkyl RH radical.It is necessary to use RH groups with donor character and also electrophilic groups present on the radicals can facilitate the breaking of the RH-O bond.As examples, ethers with Me3SiCH2CH2 or CH2=CH-CH2 groups allowed reactions to occur readily at room temperature or below using common Lewis acids such as ZnCl2, BF3-Et2O, AlCl3.