96322-91-7

Upstream product

• 78-94-4 methyl vinyl ketone 
• 2129-89-7 diphenyl(methyl)phosphine oxide 

Downstream Products

• 96302-86-2 (E)-1-cyclohexylidene-2-methylbut-2-en-4-ol 
• 96302-85-1 (E)-1-Diphenylphosphinoyl-1-(1-hydroxycyclohexyl)-2-methylbut-2-en-4-ol 
• 96302-78-2 (Z)-4-Diphenylphosphinoyl-3-methylbut-2-en-1-ol 
• 96302-77-1 (E)-4-Diphenylphosphinoyl-3-methylbut-2-en-1-ol 
• 96302-88-4 (E)-4-(Diphenyl-phosphinoyl)-3-methyl-hept-2-ene-1,5-diol 
• 96302-68-0 (Z)-1-acetoxy-4-diphenylphosphinoyl-3-methylbut-2-ene 
• 96302-67-9 (E)-1-acetoxy-4-diphenylphosphinoyl-3-methylbut-2-ene 

Relevant academic research and scientific papers

TRANSPOSITION OF ALLYLIC ALCOHOLS CONTROLLED BY THE Ph2PO GROUP: REAGENTS FOR α-HYDROXY-DIENE SYNTHESIS BY THE HORNER-WITTIG REACTION

4-Hydroxy-2-alkenyldiphenylphosphine oxides, prepared by a phosphorus-controlled allylic rearrangement, give dianions and hence α-hydroxydienes (substitued penta-2,4-dienols) by the Horner-Wittig reaction.

The Synthesis of (Z)-Penta-2,4-dien-1-ol and Substituted (E)-Pentadienols by the Stereochemically Controlled Horner-Wittig Reaction

Acylation of Ph2P(O)Me with a lactone gives a Horner-Wittig intermediate with a Z-double bond protected as a Diels-Alder adduct with furan and hence (Z)-penta-2,4-dien-1-ol.Substituted (E)-penta-2,4-dien-1-ols are available by a more general route involving addition of enals to phosphine oxides, a regiochemically controlled allylic alcohol transposition, and a Horner-Wittig reaction.The geometry of only one double bond can be controlled.