964-41-0Relevant academic research and scientific papers
Iron-Catalyzed C-H Sulfonylmethylation of Indoles in Water-PEG400
Cui, Tian-Wei,Hao, Xin-Qi,Lu, Shuai,Song, Mao-Ping,Yan, Ke-Xin,Zhu, Xinju,Zhu, Yu-Shen
supporting information, p. 1924 - 1928 (2019/09/30)
An iron-catalyzed C-H sulfonylmethylation of indoles in water-PEG400 has been developed using p -toluenesulfonylmethyl isocyanide. This protocol enables direct regioselective construction of Csp 2 -Csp 3 bond at the C3 position of indoles with a broad range of substrate compatibility in moderate to good yields, which is cost-effective and environmentally friendly.
Reactivity of p-Toluenesulfonylmethyl Isocyanide: Iron-Involved C-H Tosylmethylation of Imidazopyridines in Nontoxic Media
Lu, Shuai,Zhu, Xinju,Li, Ke,Guo, Yu-Jing,Wang, Meng-Dan,Zhao, Xue-Mei,Hao, Xin-Qi,Song, Mao-Ping
, p. 8370 - 8377 (2016/09/28)
A novel iron-involved tosylmethylation of imidazo[1,2-α]pyridines with p-toluenesulfonylmethyl isocyanide in a solvent mixture of H2O and PEG400 under an Ar atmosphere has been developed. This protocol provides a facile synthetic route for the functionalization of the imidazo[1,2-α]pyridine scaffold with broad substrate compatibility, which is less expensive and environmentally friendly. The current methodology could further enable regioselective C-H tosylmethylation of indole at the C3 position. Also, p-toluenesulfonylmethyl isocyanide was utilized as the tosylmethylating reagent for the first time.
Catalyst-free synthesis of 3-(1-arylsulfonylalkyl)indoles via three-component reaction of indoles, carbonyls, and arenesulfinic acids
Huang, Wenzhong,Yang, Juan,Li, Xiangguang,Yuan, Lin,Ma, Yinhai,Zhou, Qinglong,Liang, Deqiang
supporting information, p. 772 - 777 (2016/05/09)
A catalyst-free three-component reaction of indoles, carbonyls, and arenesulfinic acids performed at room temperature provides direct access to biologically important 3-(1-arylsulfonylalkyl)indoles. This process features mild conditions, low cost, broad s
