96400-54-3Relevant academic research and scientific papers
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
Li, Ke,Ou, Jinjie,Gao, Shuanhu
supporting information, p. 14778 - 14783 (2016/11/23)
A flexible strategy for constructing natural products containing indolizinone or quinolizinone scaffolds and their analogues was developed, which was based on a cascade exo hydroamination followed by spontaneous lactamization. This method was applied in the total synthesis of camptothecin in nine steps in a new ring-forming approach. It was also used to efficiently prepare five biogenetically or structurally related natural alkaloids, including 22-hydroxyacuminatine, oxypalmatine, norketoyobyrine, naucleficine, and nauclefine, as well as 35 natural-product-like molecules. We believe that this method and the small-molecule library prepared with it can open new avenues for studying the bioactivity of camptothecin and Nauclea natural products.
Photocyclization of enamides. XXXIV. A practical total synthesis of aromatic yohimboid alkaloids, oxogambirtannine and naucleficine
Naito,Kuroda,Miyata,Ninomiya
, p. 2216 - 2218 (2007/10/02)
Total synthesis of naucleficine (3a) was accomplished for the first time via an alkaloid, oxogambirtannine (3b), which was efficiently prepared by photocyclization of the o-methoxy-enamide 2b. The method is a practical one, suitable for large-scale preparation.
TOTAL SYNTHESIS OF NAUCLEA ALKALOID NAUCLEFICINE
Naito, Takeaki,Doi, Etsuko,Miyata, Okiko,Ninomiya, Ichiya
, p. 903 - 906 (2007/10/02)
The first total synthesis of naucleficine (1), an alkaloid of Nauclea officinalis, was achieved according to the route involving enamide photocyclization.
