96529-87-2Relevant academic research and scientific papers
An efficient synthesis and antimicrobial evaluation of 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles
Tarasenko, Marina,Sidneva, Vera,Belova, Alexandra,Romanycheva, Anna,Sharonova, Tatyana,Baykov, Sergey,Shetnev, Anton,Kofanov, Eugeniy,Kuznetsov, Mikhail A.
, p. 458 - 470 (2018)
The cyclodehydration of O-acylamidoximes at room temperature in the superbase system KOH/DMSO represents a simple and efficient way to 5-alkenyl- and 5-styryl-1,2,4-oxadiazoles. This method is suitable for the preparation of 5-(4-vinylphenyl)-1,2,4-oxadia
Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
Sharonova, Tatyana,Pankrat'eva, Vitalina,Savko, Polyna,Baykov, Sergey,Shetnev, Anton
supporting information, p. 2824 - 2827 (2018/06/13)
A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported.
One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using Catalytic System NaOH?DMSO
Pankrat’eva,Sharonova,Tarasenko,Baikov,Kofanov
, p. 1250 - 1255 (2018/10/24)
One-pot convenient process was developed for the production of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with anhydrides or acyl chlorides in a system NaOH?DMSO. The reaction proceeds at room temperature with high yields.
NBS-mediated practical cyclization of N-acyl amidines to 1,2,4-oxadiazoles via oxidative N?O bond formation
Li, Ertong,Wang, Manman,Wang, Zhen,Yu, Wenquan,Chang, Junbiao
, p. 4613 - 4618 (2018/07/31)
A reaction involving an efficient NBS-mediated oxidative N?O bond formation has been established for the synthesis of 1,2,4-oxadiazoles from readily accessible N-acyl amidines. The features of this synthetic method include simplicity of operation, mild re
Δ2-1,2,4-oxadiazolines by condensation of amidoximes with ketones and aldehydes
Lessel
, p. 383 - 389 (2007/10/02)
Using acetic acid as a solvent, ketones and aromatic aldehydes react with amidoximes 1 to cyclic products, Δ2-1,2,4-oxadiazolines 3. The lack of reactivity in neutral milieu is explained by MNDO calculations. Protonated carbonyl compounds are discussed to be the reactive species.
The Cycloaddition Reaction of Cinnamonitrile with Benzo- and Mesitonitrile Oxide
Corsaro, Antonio,Chiacchio, Ugo,Perrini, Giancarlo,Caramella, Pierluigi,Purrello, Giovanni
, p. 3449 - 3464 (2007/10/02)
The reactivity, site- and regio-selectivity of the cycloaddition reaction of cinnamonitrile with the title nitrile oxides have been examined and discussed.The previously investigated behaviour of β-aminocinnamonitriles towards nitrile oxides is also discu
