96557-31-2Relevant academic research and scientific papers
Direct synthesis of protected arylacetaldehydes by tetrakis(phosphane)- palladium-catalyzed arylation of ethyleneglycol vinyl ether
Kondolff, Isabelle,Doucet, Henri,Santelli, Maurice
, p. 765 - 774 (2007/10/03)
A range of aryl bromides undergo Heck reaction with ethylene glycol vinyl ether, in the presence of [PdCl(C3H5)]2/ cis,cis,cis-1,2,3,4-tetrakis[(diphenylphosphanyl)methyl]cyclopentane as catalyst, to give regioselectively protected arylacetaldehydes in good yields. The β-arylation products were obtained in with 93-100 % selectivity with electron-poor aryl bromides or heteroaryl bromides. Furthermore, this catalyst can be used at low loading, even for reactions with sterically hindered aryl bromides. The aryl vinyl ether intermediates undergo subsequent ketalisation to give the corresponding 2-benzyl-1,3-dioxolane derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Direct synthesis of protected arylacetaldehydes by palladium- tetraphosphine-catalyzed arylation of ethyleneglycol vinylether
Kondolff, Isabelle,Doucet, Henri,Santelli, Maurice
, p. 1561 - 1564 (2007/10/03)
Through the use of [PdCl(C3H5)]2/cis,cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl) cyclopentane as a catalyst, a range of aryl bromides undergo Heck reaction with ethyleneglycol vinylether to give regioselectively protected arylacetaldehydes in good yields. The β-arylation products were obtained in the range 93-98% selectivity with electron-poor aryl bromides. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered aryl bromides. The arylvinyl ethers intermediates undergo subsequent ketalization to give the corresponding 2-benzyl-1,3-dioxolane derivatives.
Iminium Ion Mediated Cyclizations of 4-Aryl-1,4-dihydropyridines. Bridging with Acetals, Carbonyls, and Thiocarbonyls
Hartman, George D.,Phillips, Brian T.,Halczenko, Wasyl
, p. 2423 - 2427 (2007/10/02)
The preparation of new aldehyde and acetal derivatives of 4-aryl-1,4-dihydropyridines has been carried out.Treatment of these compounds under acid conditions affords novel caged molecules derived from sequential intramolecular addition reactions.This proc
