96561-04-5

Basic information

• Product Name: BOC-D-LYS(TFA)-OH
• Synonyms: BOC-D-LYSINE(TFA)-OH;BOC-D-LYS(TFA)-OH;BOC-N-EPSILON-TFA-D-LYSINE;BOC-N-EPSILON-TRIFLUOROACETYL-D-LYSINE;N-ALPHA-T-BUTOXYCARBONYL-N-EPSILON-TRIFLUOROACETYL-D-LYSINE;BOC-N-E-TFA-D-LYSINE;N2-Boc-N6-(Trifluoroacetyl)-D-lysine;(R)-2-((tert-Butoxycarbonyl)aMino)-6-(2,2,2-trifluoroacetaMido)hexanoic acid
• CAS NO: 96561-04-5
• Molecular Formula: C₁₃H₂₁F₃N₂O₅
• Molecular Weight: 342.31
• Mol File: 96561-04-5.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: -15°C
• CAS DataBase Reference: BOC-D-LYS(TFA)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-LYS(TFA)-OH(96561-04-5)
• EPA Substance Registry System: BOC-D-LYS(TFA)-OH(96561-04-5)

Safety Data

• Hazardous Substances Data: 96561-04-5(Hazardous Substances Data)

Usage

Uses

Used in Peptide Synthesis:
BOC-D-LYS(TFA)-OH is used as a building block in peptide synthesis for the creation of complex peptide sequences. The BOC group protects the amine group during the synthesis process, preventing unwanted side reactions and ensuring the correct formation of peptide bonds.
Used in Biochemical Research:
In biochemical studies, BOC-D-LYS(TFA)-OH is used as a starting material to generate free amine groups on lysine residues. This is crucial for the investigation of protein structure, function, and interactions, as well as for the development of new bioactive peptides and drugs.
Used in Pharmaceutical Industry:
BOC-D-LYS(TFA)-OH is used as an intermediate in the synthesis of pharmaceutical compounds, particularly in the development of peptide-based drugs. BOC-D-LYS(TFA)-OH's ability to be selectively deprotected and coupled with other molecules makes it a valuable tool in medicinal chemistry for creating novel therapeutic agents.
Used in Drug Delivery Systems:
In the field of drug delivery, BOC-D-LYS(TFA)-OH can be incorporated into the design of drug carriers and conjugates. BOC-D-LYS(TFA)-OH's functional groups can be utilized to attach drugs to delivery systems, such as nanoparticles or polymers, to improve the targeting, stability, and bioavailability of therapeutic agents.
Used in Chemical Synthesis:
BOC-D-LYS(TFA)-OH is used as a reagent in various chemical synthesis processes, including the preparation of chiral compounds, catalysts, and other specialty chemicals. BOC-D-LYS(TFA)-OH's unique structure and functional groups make it a versatile building block for the creation of new molecules with specific properties and applications.

Upstream product

• 383-64-2 S-ethyl trifluoroacetate 
• 13734-28-6 Boc-Lys-OH 
• 383-63-1 ethyl trifluoroacetate, 
• 84624-27-1 Boc-Lys(Fmoc)-OH 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10009-20-8 (S)-6-trifluoroacetylamino-2-aminohexanoic acid 

Downstream Products

• 77829-75-5 C₂₀H₂₈F₃N₃O₅ 
• 142846-53-5 Boc-Lys(COCF₃)-Gly-OCH₂Ph 
• 142824-66-6 Boc-Lys(COCF₃)-Lys(COCF₃)-Gly-OCH₂Ph 
• 34695-46-0 N-alpha-BOC-N-epsilon-TFA-lysine succinimidyl ester 
• 1242276-50-1 C₂₇H₃₇F₃N₄O₅ 
• 1375701-67-9 α-N-Boc-ε-N-trifluoroacetyl-lysine-CBT 

Relevant articles and documents

Control of lysyl oxidase activity through site-specific deuteration of lysine

Lysyl oxidase (LOX) is implicated in several extracellular matrix related disorders, including fibrosis and cancer. Methods of inhibition of LOX in vivo include antibodies, copper sequestration and toxic small molecules such as β-aminopropionitrile. Here,

THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE

Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.

Synthesis of a radioiodinated park nucleotide analog: A new tool for antibacterial screen development

The Park nucleotide is an important biological building block used in the construction of bacterial cell walls. Herein, we describe the synthesis of a radiolabeled Park nucleotide analog, p-iodophenoxyacyl-Ala-(D)-iso- GluLys-(D)-Ala-(D)-Ala-OH-[125

Reversible protection of lysine to facilitate the purification of protected peptide segments

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.