96566-00-6Relevant articles and documents
Design and synthesis of novel 3,4-dihydrocoumarins as potent and selective monoamine oxidase-B inhibitors with the neuroprotection against Parkinson's disease
Liu, Li,Chen, Yi,Zeng, Rui-Feng,Liu, Yun,Xie, Sai-Sai,Lan, Jin-Shuai,Ding, Yue,Yang, Yi-Ting,Yang, Jun,Zhang, Tong
, (2021)
The monoamine oxidase-B (MAO-B) inhibitors with neuroprotective effects are better for Parkinson's disease (PD) treatment, due to the complicated pathogenesis of PD. To develop new hMAO-B inhibitors with neuroprotection, a novel series of 3,4-dihydrocouma
Dihydrocoumarin derivatives as well as preparation method and application thereof
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Paragraph 0043; 0045-0047, (2017/05/13)
The invention relates to the medical field and discloses dihydrocoumarin derivatives which are compounds shown in formula I or pharmaceutically acceptable salts of the compounds in formula I. The compounds are prepared from substitute 7-hydroxyl dihydroco
PREVENTIVE OR THERAPEUTIC AGENT FOR KIDNEY DISEASE
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Page 21, (2008/06/13)
The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted alkyl group; R2 is a dialkylamino group, an alkyl group, a cycloalkyl group, an optionally substituted aryl group etc.; T is an oxygen atom, a sulfur atom etc.; Q is a hydrogen atom or an optionally substituted alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof which has an inhibitory effect on mesangial cell proliferation and a decreasing effect on protein excretion in urine, and are useful for preventing or treating of various renal diseases such as IgA nephropathy, diabetic nephropathy, nephritic syndrome and the like.