96602-46-9Relevant articles and documents
Design and synthesis of photoaffinity-labeling ligands of the L-prolyl-L-leucylglycinamide binding site involved in the allosteric modulation of the dopamine receptor
Fisher, Abigail,Mann, Amandeep,Verma, Vaneeta,Thomas, Nancy,Mishra, Ram K.,Johnson, Rodney L.
, p. 307 - 317 (2007/10/03)
Pro-Leu-Gly-NH2 (PLG), in addition to its endocrine effects, possesses the ability to modulate dopamine 02 receptors within the central nervous system. However, the precise binding site of PLG is unknown. Potential photoaffinity-labeling ligand
Polypeptides from Murine Peritoneal Macrophages that Bind Glucosaminylmuramyldipeptides
Golovina, T. N.,Sumaroka, M. V.,Samokhvalova, L. V.,Shebzukhov, Yu. V.,Makarov, E. A.,Nesmeyanov, V. A.
, p. 230 - 235 (2007/10/02)
The surfaces of murine peritoneal macrophages were shown to express several hundred high-affinity GMDP-binding sites with a binding constant of 350 pM by radioligand analysis.Photoaffinity labeling followed by SDS-PAGE enabled the identification of 32-34
PHOTOAFFINITY PROBES FOR GIBBERELLIN-BINDING PROTEINS
Beale, Michael H.,Hooley, Richard,Smith, Sally J.,Walker, Robert P.
, p. 1459 - 1464 (2007/10/02)
A rational approach to the design, synthesis and radiolabelling, with either 3H or 125I, of gibberellin A4 (GA4) derivatives containing C-17-arylazido functionalities is described.The potential of these compounds as photoaffinity rea
Synthesis and biological activity of iodinated and photosensitive derivatives of tetrabenazine
Aranda,Beaucourt,Ponchant,Isambert,Henry
, p. 369 - 374 (2007/10/02)
The synthesis of a photosensitive iodinated derivative of tetrabenazine, which should be able to lead to the identification of the vesicular catecholamine transporter of adrenal medulla by photoaffinity, is described in detail. The biological activity of this iodinated ligand was found to be significantly lower than that of non iodinated ligands.
As asymmetrical disulfide-containing photoreactive heterobifunctional reagent designed to introduce radioactive labeling into biological receptors
Dupuis, Gilles
, p. 2450 - 2453 (2007/10/02)
The synthesis of succinimido 1-amino-(4-azidosalicyloyl)-3,4-dithio-5-carboxylate, a heterobifunctional photoaffinity labeling reagent, is described.The cross-linker possesses an asymmetrical disulfide bond, and a general method for generating a spacer ar