96616-16-9Relevant academic research and scientific papers
A simple one-pot procedure for preparing symmetrical diaryllureas from carbon dioxide and aromatic amines
Cooper,Falcone
, p. 2467 - 2474 (1995)
Symmetrical diarylureas can be prepared by purging an aromatic amine with carbon dioxide in the presence of a strong amidine base followed addition of solid commercially available Me3N·SO3. Work up is simply by dilution with water. The procedure is far simpler and safer than traditional methods using phosgene or isocyanates.
Novel Bis as Antitrypanosomal Agents
Turner, William R.,Werbel, Leslie M.
, p. 1728 - 1740 (2007/10/02)
A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.
