96679-53-7Relevant academic research and scientific papers
A Robust, Recyclable Resin for Decagram Scale Resolution of (±)-Mefloquine and Other Chiral N-Heterocycles
Kreituss, Imants,Chen, Kuang-Yen,Eitel, Simon H.,Adam, Jean-Michel,Wuitschik, Georg,Fettes, Alec,Bode, Jeffrey W.
supporting information, p. 1553 - 1556 (2016/02/12)
Decagram quantities of enantiopure (+)-mefloquine have been produced via kinetic resolution of racemic mefloquine using a ROMP-gel supported chiral acyl hydroxamic acid resolving agent. The requisite monomer was prepared in a few synthetic steps without chromatography and polymerization was safely performed on a >30 gram scale under ambient conditions. The reagent was readily regenerated and reused multiple times for the resolution of 150 grams of (±)-mefloquine and other chiral N-heterocylces.
4-phenyl-tetrahydro-furano-pyridines and anti-depressant pharmaceutical compositions containing same
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, (2008/06/13)
The invention relates to 4-phenyl-tetrahydro-furano-pyridines of the formulas STR1 wherein R1 to R5 are variously defined. The compounds of the invention are intended to be used as anti-depressants with, in particular, thymoleptic an
