96706-35-3Relevant academic research and scientific papers
The synthesis of 6,9-difluorobenzo[g]quinoline-5,10-dione. Displacements of the fluorides by diamines which lead to 6,9- bis[(aminoalkyl)amino]benzo[g]quinoline-5,10-diones
Krapcho,Petry,Landi Jr.,Stallman,Polsenberg,Hacker,Spinelli,Oliva,Di Domenico,Menta
, p. 1565 - 1570 (2007/10/02)
The synthesis of 6,9-difluorobenzo[g]quinoline-5,10-dione (3b) is described. Facile ipso substitutions of the fluorides from 3b by diamines readily yield the corresponding 6,9-bis[(aminoalkyl)amino]benzo[g]quinoline- 5,10-diones 2. The analogue 2d has been synthesized by side arm modifications of dione 8a.
Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones
Krapcho,Landi Jr.,Hacker,McCormack
, p. 1124 - 1126 (2007/10/02)
Several 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones have been synthesized and evaluated for antitumor activity against L1210 leukemia both in vitro and in vivo. Comparisons are made to the corresponding carbocyclic analogues. One of the aza analogues showed modest in vivo activity.
