96746-54-2Relevant academic research and scientific papers
5-Benzyl-1H-tetrazols from the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene
Aly, Ashraf A.,Shaker, Raafat M.
, p. 2679 - 2682 (2007/10/03)
A series of 1-aryl-5-benzyl-1H-tetrazoles has been obtained during the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene. The mechanism of product formation was investigated.
The Chemistry of 5-Oxodihydroisoxazoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl)propanoic Acids
Caiazza, Daniela,Prager, Rolf H.,Schafer, Karl
, p. 1861 - 1872 (2007/10/03)
A number of N-arylisoxazol-5(2H)-ones (aryl = phenyl, isoquinolin-1-yl, quinolin-2-yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl)acetic esters, which have been C-methylated and hydrolysed.The resulting 2-(1-aryltetrazol-5-yl)propanoic acid had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE2 or tumor necrosis factor α.
SYNTHESIS OF 1,5-SUBSTITUTED TETRAZOLES FROM SECONDARY THIOAMIDES
Lehnhoff, Stefan,Ugi, Ivar
, p. 801 - 808 (2007/10/02)
A new, rather simple method for the conversion of thiamides and similar structures into 1,5-substituted tetrazoles is described.The procedure employs TMS-N3 and mild Lewis acid, like SnCl4 in an inert solvent at room temperature and leads to high yields.Such compounds are of increasing interest for their pharmaceutical properties.
Nucleophilic Attacks on Carbon-Carbon Double Bonds. 31. Complete and Partial Stereoconversion in Vinylic Substitution of (E)- and (Z)-β-Chloro-α-phenylcinnamaldehydes and (E)-2-Iodo-1,2-diphenyl-1-nitroethylene by Nucleophiles
Rappoport, Zvi,Gazit, Aviv
, p. 3184 - 3194 (2007/10/02)
Substitution of the chlorine of (E)- and (Z)-α-chloro-β-phenylcinnamaldehydes ((E)- and (Z)-5) by p-toluenethiolate (ArS-), p-cresolate (ArO-), and MeO- ions proceeds with complete or partial stereoconversion.With ArS
