96746-54-2Relevant academic research and scientific papers
5-Benzyl-1H-tetrazols from the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene
Aly, Ashraf A.,Shaker, Raafat M.
, p. 2679 - 2682 (2007/10/03)
A series of 1-aryl-5-benzyl-1H-tetrazoles has been obtained during the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene. The mechanism of product formation was investigated.
SYNTHESIS OF 1,5-SUBSTITUTED TETRAZOLES FROM SECONDARY THIOAMIDES
Lehnhoff, Stefan,Ugi, Ivar
, p. 801 - 808 (2007/10/02)
A new, rather simple method for the conversion of thiamides and similar structures into 1,5-substituted tetrazoles is described.The procedure employs TMS-N3 and mild Lewis acid, like SnCl4 in an inert solvent at room temperature and leads to high yields.Such compounds are of increasing interest for their pharmaceutical properties.
The Chemistry of 5-Oxodihydroisoxazoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl)propanoic Acids
Caiazza, Daniela,Prager, Rolf H.,Schafer, Karl
, p. 1861 - 1872 (2007/10/03)
A number of N-arylisoxazol-5(2H)-ones (aryl = phenyl, isoquinolin-1-yl, quinolin-2-yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl)acetic esters, which have been C-methylated and hydrolysed.The resulting 2-(1-aryltetrazol-5-yl)propanoic acid had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE2 or tumor necrosis factor α.
Nucleophilic Attacks on Carbon-Carbon Double Bonds. 31. Complete and Partial Stereoconversion in Vinylic Substitution of (E)- and (Z)-β-Chloro-α-phenylcinnamaldehydes and (E)-2-Iodo-1,2-diphenyl-1-nitroethylene by Nucleophiles
Rappoport, Zvi,Gazit, Aviv
, p. 3184 - 3194 (2007/10/02)
Substitution of the chlorine of (E)- and (Z)-α-chloro-β-phenylcinnamaldehydes ((E)- and (Z)-5) by p-toluenethiolate (ArS-), p-cresolate (ArO-), and MeO- ions proceeds with complete or partial stereoconversion.With ArS
