96756-05-7

Upstream product

• 75-36-5 acetyl chloride 
• 96756-21-7 2-Nonyl-benzene-1,3,5-triol 
• 916916-60-4 3-n-nonyl-2,4,6-trimethoxyacetophenone 
• 74478-11-8 2,4,6-trihydroxynonanophenone 
• 764-85-2 Nonanoyl chloride 
• 108-73-6 3,5-dihydroxyphenol 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 916916-53-5 2-n-nonyl-1,3,5-trimethoxybenzene 

Downstream Products

• 916916-87-5 3-n-nonyl-2-hydroxy-4,6-bis(methoxymethoxy)acetophenone 
• 916917-22-1 8-n-nonyl-5,7,4'-tris(methoxymethoxy)flavanone 

Relevant academic research and scientific papers

Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors α and β

In search of therapeutic agents for estrogen-related pathologies, phytoestrogens are being extensively explored. In contrast to naringenin, 8-prenylnaringenin is a potent hop-derived estrogenic compound, highlighting the importance of the prenyl group for hormonal activity. We investigated the effects of substituting the prenyl group at C(8) with alkyl chains of varying lengths and branching patterns on estrogen receptor (ER) subtype ERα- and ERβ-binding affinities and transcriptional activities. In addition, features of the ligand-induced receptor conformations were explored using a set of specific ER-binding peptides. The new 8-alkylnaringenins were found to span an activity spectrum ranging from full agonism to partial agonism to antagonism. Most strikingly, 8-(2,2-dimethylpropyl)naringenin exhibited full agonist character on ERα, but pronounced antagonist character on ERβ. Knowledge on how ER-subtype-selective activities can be designed provides valuable information for future drug or tool compound discovery.

Antifungal Activities of 2,4,6-Trihydroxyacylophenones and Related Compounds

The antifungal activities of sixty two 2,4,6-trihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to study their structure-activity relationship.It was found that the activities of these compounds were closely related to the length of the acyl and alkyl chains attached to the 1,3,5-trihydroxybenzene moiety.Among the compounds tested, 2,4,6-trihydroxy-3-nonylacetophenone (V-7) showed the highest activity against Trichophyton spp., with MICs being 1.57 μg/ml, and was more active than amphotericin B.