96808-02-5Relevant academic research and scientific papers
Procedures for the Acylation of Diethyl Malonate and Ethyl Acetoacetate with Acid Chlorides Using Tertiary Amine Bases and Magnesium Chloride
Rathke, Michael W.,Cowan, Patrick J.
, p. 2622 - 2624 (1985)
In the presence of magnesium chloride and 2 equiv of triethylamine, diethyl malonate is C-acylated in excellent yields by acid chlorides.A variety of other metal chlorides were ineffective.Similarly, ethyl acetoacetate is C-acylated by acid chlorides in the presence of magnesium chloride and 2 equiv of pyridine.
