96813-44-4

Upstream product

• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 107-15-3 ethylenediamine 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 81677-62-5 3-(4-Nitrophenyl)propane-1,2-diamine 
• 63-91-2 L-phenylalanine 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 

Downstream Products

• 96813-36-4 2-amino-3-(4-nitrophenyl)propyl (2'-aminoethyl)amine 
• 262855-60-7 tert-butyl 2-[(2-{bis[2-(tert-butoxy)-2-oxoethyl]amino}-3-(4-nitrophenyl)propyl)(2-{bis[2-(tert-butoxy)-2-oxoethyl]amino}ethyl)amino]acetate 
• 603957-80-8 N,N'-bis(2-hydroxybenzyl)-2-(p-nitrobenzyl)-3-monooxo-1,4,7-triazaheptane 

Relevant academic research and scientific papers

Trivalent Gd-DOTA reagents for modification of proteins

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer (e.g., gadolinium(III) complexes such as Gd-DOTA), without losing affinity

Nanofibers and morphology shifting micelles

The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.

METHODS OF COLLAGEN IMAGING

Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.

Synthesis of novel bifunctional Schiff-base ligands derived from condensation of 1-(p-nitrobenzyl)ethylenediamine and 2-(p-nitrobenzyl)-3-monooxo-1,4,7-triazaheptane with salicylaldehyde

Two potentially tetradentate (N2O2) and pentadentate (N3O3) bifunctional Schiff-base ligands, N,N′-bis(2-hydroxybenzyl)-1-(p-aminobenzyl)ethylenediamine (7) and N,N′-bis(2-hydroxybenzyl)-2-(p-aminobenzyl)-3-monooxo-1,4,7- triazaheptane (5′) have been prepared and characterized by various spectroscopic methods (IR, FAB-MS, NMR). They are derived from the condensation reactions of the C-functionalized diamines 1-(p-nitrobenzyl)ethylenediamine and 2-(p-nitrobenzyl)-3-monooxo-1,4,7-triazaheptane with 2.1 equiv. of salicylaldehyde. The first complexation trials with 99mTc are reported.