96829-91-3

Basic information

• Product Name: Methanone, (4-methoxyphenyl)(5-phenyl-2-oxazolyl)-
• CAS NO: 96829-91-3
• Molecular Formula: C17H13NO3
• Molecular Weight: 279.295
• Mol File: 96829-91-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Methanone, (4-methoxyphenyl)(5-phenyl-2-oxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-methoxyphenyl)(5-phenyl-2-oxazolyl)-(96829-91-3)
• EPA Substance Registry System: Methanone, (4-methoxyphenyl)(5-phenyl-2-oxazolyl)-(96829-91-3)

Safety Data

• Hazardous Substances Data: 96829-91-3(Hazardous Substances Data)

Upstream product

• 1006-68-4 5-phenyloxazole 
• 96829-98-0 4-methoxy-N-methyl-N-(pyridine-2-yl)benzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 701-53-1 p-methoxybenzoyl fluoride 
• 5344-83-2 2-(hydroxyimino)-1-(4-methoxyphenyl)propan-1-one 
• 121-97-1 4-Methoxypropiophenone 
• 20662-89-9 4-phenyl-1,3-oxazole 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 

Relevant articles and documents

Synthesis of Acyl Fluorides via DAST-Mediated Fluorinative C-C Bond Cleavage of Activated Ketones

A new protocol for preparation of acyl fluorides was developed by recognizing activated ketones as starting materials. The method provides a different scope compared with previously reported methods that employ carboxylic acids as substrates. A working hypothesis of pull-and-push-driven fluorinative C-C bond cleavage was successfully demonstrated by the simple addition of diethylaminosulfur trifluoride (DAST) derivatives to α-oximinoketones. The designed reaction system led to a highly efficient and chemoselective reaction. The wide availability of the ketones allowed for a range of synthetically useful aryloyl and aliphatic acyl fluorides including those containing chiral skeletons. The method is mild, fast, scalable, and potentially one-pot operative.

Catalytic C?H/C?F Coupling of Azoles and Acyl Fluorides

A method for the palladium/copper-catalyzed direct acylation of azoles with acyl fluorides is described. This study reports the first examples of acyl fluorides being used as acylation reagents in transition-metal-catalyzed aromatic C?H bond functionalization reactions. Depending on the reaction temperature, decarbonylative coupling may also occur. Mechanistic studies suggest that the cleavage of the aromatic C?H bond, promoted by a copper-phosphine species, is not the rate-limiting step of this acylation.

Acylation of oxazoles by the copper-mediated reaction of oxazol-2-ylzinc chloride derivatives

C-2 acylation of oxazole derivatives is accomplished by reaction of oxazol-2-ylzinc chloride reagents with acid chlorides in the presence of cuprous iodide. O-acylated vinylisonitriles, which are the sole product from the corresponding reaction employing