96841-94-0

Upstream product

• 854645-25-3 methyl 3-(iodomethyl)benzoate 
• 67-56-1 methanol 
• 4380-99-8 1,2-bis(3-carboxyphenyl)ethane 
• 591-17-3 meta-bromotoluene 
• 823-78-9 meta-bromobenzyl bromide 
• 4381-01-5 1,2-bis(3-cyanophenyl)ethane 
• 82732-03-4 1,1'-(1,2-ethanediyl)bis-3-bromobenzene 
• 603-35-0 triphenylphosphine 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 56981-97-6 3-methoxycarbonyl-benzyl-triphenylphosphonium bromide 

Downstream Products

• 121262-86-0 1,2-Bis<3-(brommethyl)phenyl>ethan 
• 108843-01-2 3,3'-bis(hydroxymethyl)diphenylethane 

Relevant academic research and scientific papers

Reactions of benzyltriphenylphosphonium salts under photoredox catalysis

The development of benzyltriphenylphosphonium salts as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method.

Straightforward synthesis of substituted dibenzyl derivatives

The C-C bond formation by homogeneous catalysis is a powerful tool in organic synthesis. The replacement of noble metal by cheaper one for already reported methodologies is of interest for an economical purpose. The attractivity of such replacement is also enhanced if a first raw transition metal is found to be active in several processes. This work demonstrates that a common nickel complex can be used for a two-step cross-coupling procedure, namely a homocoupling reaction of benzyl derivatives and a subsequent Suzuki reaction. These consecutive reactions permit the synthesis of new polyfunctionalized dibenzyl compounds.

1,2-Ethylene-3,3-bis(4′,4″-dimethoxytrityl chloride) (E-DMT): Synthesis and applications of a novel protecting reagent

1,2-Ethylene-3,3-bis(4′,4″-dimethoxytrityl chloride), (E-DMT) was developed as a novel, bifunctional protecting reagent. This new compound was found to have a potential as a multipurpose acid-labile protecting reagent which can afford a 5′,5′-tritylthymidine dimer and a unique 5′,3′-cyclic protected thymidine derivative in modest to good yields.

REDUCTIVE COUPLING OF BENZYL HALIDES USING NICKEL(0)-COMPLEX GENERATED IN SITU IN THE PRESENCE OF TETRAETHYLAMMONIUM IODIDE, A SIMPLE AND CONVENIENT SYNTHESIS OF BIBENZYLS

Zerovalent nickel complex generated in situ by reduction of NiBr2(PPh3)2 with zinc powder in the presence of Et4NI was found to be an effective catalyst for homo-coupling of benzyl halides.The catalytic reactions proceeded smoothly in various solvents under mild conditions to afford dehalogenative-coupling products in good to high yields.