96846-37-6Relevant academic research and scientific papers
Ring opening reactions of cyclic sulfamidates. Synthesis of β-fluoroaryl alanines and derivatives of 4,4-difluoroglutamic acid
Bolek, Sylwia,Ignatowska, Jolanta
, p. 13 - 21 (2018/11/24)
Ring opening reactions of 1 with copper complex formed between Cu, TMEDA and BrCF2CO2Et lead to optically active 4,4-difluoroglutamic acid derivatives 11a-d in moderate yields. Reaction of cyclic sulfamidates 1 with fluoro substituted arylmagnesium chlorides proceed via copper catalyzed 1,4-addition of Grignard reagent to dehydroalanine 2, formed in situ. Fluorinated organoznic derivatives were unreactive towards 1 regardless of the reaction conditions; instead product of reaction of 1 with DMF was isolated.
Diastereoselective alkylations of a protected cysteinesulfenate
Schwan, Adrian L.,Verdu, Marcus J.,Singh, Suneel P.,O'Donnell, Jennifer S.,Ahmadi, Amir Nasser
experimental part, p. 6851 - 6854 (2009/12/31)
(Chemical Equation Presented) To further understand stereoselection in the alkylation of sulfenate anions, a protected cysteinesulfenate was generated in THF solution at low temperature. Introduction of a reactive alkylating agent brings about a cysteinyl
