96869-84-0Relevant academic research and scientific papers
Palladium-Catalyzed Ylidyl-Carbonylation of Aryl Halides to Produce α-Acylphosphoranes
Guo, Xiaojun,Ma, Wei,Xue, Dong,Wang, Chao,Xiao, Jianliang
supporting information, p. 4824 - 4827 (2016/10/14)
An efficient synthesis of α-acylphosphoranes by palladium-catalyzed carbonylation of aryl iodides with carbon monoxide and stabilized phosphonium ylides has been developed. Featuring 44 examples, the protocol displayed a wide substrate scope under mild reaction conditions, showcasing its potential in synthetic organic chemistry.
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
Grosskopf, Stefanie,Eckert, Chris,Arkona, Christoph,Radetzki, Silke,B?hm, Kerstin,Heinemann, Udo,Wolber, Gerhard,Von Kries, Jens-Peter,Birchmeier, Walter,Rademann, J?rg
, p. 815 - 826 (2015/05/05)
Selective inhibitors of the protein tyrosine phosphatase SHP2 (src homology region 2 domain phosphatase; PTPN11), an enzyme that is deregulated in numerous human tumors, were generated through a combination of chemical synthesis and structure-based ration
Synthesis of 2-amino-6-phenyl-4H-pyran-4-ones
Morris,Wishka
, p. 43 - 46 (2007/10/02)
The treatment of a series of phenylacetylenic β-keto amides with methanesulfonic acid produces a high yielding intramolecular cyclization to the corresponding 2-amino-6-phenyl-4H-pyran-4-ones.
