96896-42-3

Upstream product

• 21794-55-8 (+)-Daunomycinone 
• 54621-94-2 3,4-di-O-acetyl-L-fucal 
• 32384-98-8 7-deoxydaunomycin 
• 34819-86-8 3,4-di-O-acetyl-6-deoxy-L-glucal 

Downstream Products

• 64842-74-6 7-O-(3,4-di-O-acetyl-2,6-didesoxy-α-L-lyxo-hexopyranosyl)daunomycinone 
• 32384-98-8 7-deoxydaunomycin 
• 64842-74-6 7-O-(3,4-di-O-acetyl-2,6-dideoxy-α-L-arabino-hexopyranosyl)-daunomycinon 

Relevant academic research and scientific papers

Oxyhalogenation of glycals for the synthesis of anti-tumor-active 2'-halo daunorubicin analogs.

Alkoxyhalogenation of L-rhamnal diacetate with daunomycinone and N-iodosuccinimide afforded 37% of 7-O- (3,4-di-O-acetyl-2,6-dideoxy-2-iodo-alpha-L-mannopyranosyl)daunomycin one (4, NSC 331,962) and 7% of the beta-L-gluco analog (NSC 353,457); a similar procedure with L-fucal diacetate gave 77% of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-2-iodo-alpha-L-talopyranosyl) daunomycinone (NSC 327,472). Compound 4 showed high activity (T/C 247) and low toxicity in the P-388 lymphocytic leukemia screen in mice.