Carbohydrate research p. 391 - 396 (1985)
Update date:2022-08-04
Topics:
Horton
Priebe
Alkoxyhalogenation of L-rhamnal diacetate with daunomycinone and N-iodosuccinimide afforded 37% of 7-O- (3,4-di-O-acetyl-2,6-dideoxy-2-iodo-alpha-L-mannopyranosyl)daunomycin one (4, NSC 331,962) and 7% of the beta-L-gluco analog (NSC 353,457); a similar procedure with L-fucal diacetate gave 77% of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-2-iodo-alpha-L-talopyranosyl) daunomycinone (NSC 327,472). Compound 4 showed high activity (T/C 247) and low toxicity in the P-388 lymphocytic leukemia screen in mice.
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Doi:10.1021/acs.orglett.9b03524
(2019)Doi:10.1021/om500856p
(2014)Doi:10.1016/0008-6215(85)85209-5
(1985)Doi:10.1021/ja01329a032
(1933)Doi:10.1246/bcsj.66.1566
(1993)Doi:10.1016/S0957-4166(99)00349-3
(1999)
