96907-84-5

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 6595-28-4 2-azido-1-(4-methoxyphenyl)ethan-1-one 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 1043600-35-6 4,4'-(1,3-oxazol-2,5-diyl)diphenol 
• 97978-70-6 2-(4-methoxyphenyl)-5-(4-methoxyphenyl)-1H-imidazole 
• 54867-73-1 2-(4-methoxyphenyl)-5-(4-methoxyphenyl)oxazole 

Relevant academic research and scientific papers

Laser flash photolysis of nanocrystalline α-azido-: P -methoxy-acetophenone

Irradiation of nanocrystals of azide 1 results in a solid-to-solid reaction that forms imine 2 in high chemical yield. In contrast, solution photolysis of azide 1 yields a mixture of products, with 7 as the major one. Laser flash photolysis (LFP) of a nanocrystalline suspension of azide 1 in water shows selective formation of benzoyl radical 4 (λmax ～ 400 nm), which is short-lived (τ = 833 ns) as it intersystem crosses to form imine 2. In comparison, LFP of azide 1 in methanol reveals the formation of triplet alkylnitrene 10 (λmax ～ 340 nm). The selectivity observed in the solid-state is related to stabilization of the triplet ketone with (n,π?) configuration by the crystal lattice, which results in α-cleavage being favored over triplet energy transfer to the azido chromophore. Both the solid-state and solution reaction mechanisms are further supported by density functional theory calculations. Thus, laser flash photolysis has been used to effectively elucidate the medium dependent reaction mechanisms of azide 1.

17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-RELATED DISEASES

The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases.