96947-44-3

Upstream product

• 88588-59-4 (2S)-2-methyl-3-(tetrahydropyran-2-yloxy)propan-1-ol 
• 882-33-7 diphenyldisulfane 
• 110-87-2 3,4-dihydro-2H-pyran 
• 96882-94-9 (2S)-3-(tetrahydropyran-2-yl)oxy-1-methanesulfonyloxy-2-methylpropane 
• 88557-53-3 methyl 2(S)-methyl-3-tetrahydropyranyloxypropanoate 
• 88557-53-3 (R)-2-Methyl-3-(tetrahydro-pyran-2-yloxy)-propionic acid methyl ester 
• 108-98-5 thiophenol 
• 96882-95-0 (2rac)-{[(2R)-3-bromo-2-methylpropyl]oxy}tetrahydro-2H-pyran 

Downstream Products

• 101212-46-8 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 112995-98-9 (3RS,5R,2'R,3'S,6'S,8'S,10'R)-O-3-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1'7'-dioxaspiro<5.5>undecan-8'-yl)-3,5-dimethyl-6-thiophenylhex-1-enyl S-methyl thiocarbonate 
• 101212-42-4 (1RS,5R,2'R,3'S,6'S,8'S,10'S)-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8'-yl)-3,5-dimethyl-6-thiophenylhex-2-enol 
• 112995-95-6 (R)-(-)-2-methyl-3-phenylthiopropyl toluene-p-sulphonate 
• 101212-38-8 (4R)-(+)-2,4-dimethyl-1-iodo-5-phenylthiopent-1-ene 
• 101212-37-7 (R)-(+)-2-methyl-3-phenylthiopent-4-yne 
• 112995-96-7 (S)-2-methyl-3-phenylthiopropyl bromide 
• 101212-45-7 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'-phenylsulphonylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 
• 101212-44-6 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'thiophenylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 
• 702-00-1 (2-methylallyl)(phenyl)sulfane 
• 503443-80-9 2-((2R,6S)-3-Benzenesulfonyl-2,6,10-trimethyl-undec-9-enyloxy)-tetrahydro-pyran 
• 96947-45-4 (R)-2-methyl-1-(phenylsulfonyl)-3-(tetrahydropyranyloxy)propane 
• 101212-36-6 (R)-(-)-2-methyl-3-(phenylthio)propan-1-ol 

Relevant academic research and scientific papers

Synthetic studies on the dienophile unit of methyl isosartortuoate. Part 1: Assembly of the acyclic precursor

A strategically functionalized compound, as the acyclic precursor of the dienophile unit of methyl isosartortuoate has been synthesized, and its stereochemistry was also assigned.

Synthesis of hexadeuterated 23-dehydroxybrassinosteroids

Two hexadeuterated brassinosteroids (BS) ([26,27-2H6]-23-dehydroxycastasterone and [26,27-2H6]-cathasterone) containing a hydroxy group at C22 instead of the 22R,23R-diol function characteristic for most compounds of this class were prepared for biochemical studies. The corresponding non-deuterated compounds are considered intermediates in brassinolide biosynthesis. The carbon skeleton of the side chain with proper stereochemistry at C24 was prepared from commercially available (2R)-3-hydroxy-2-methylpropanoate. This low molecular fragment was coupled to the tetracyclic steroidal fragment through the reaction of the appropriate sulfone with C22 aldehyde. Formation of the necessary configuration of the 22-hydroxy group was achieved by hydride reduction of the corresponding ketone. Deuterium atoms at C26 and C27 originated from [2H3]methyl iodide used for alkylation of the intermediate sulfone.

Total Synthesis of (+)-Milbemycin β3

The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio

SYNTHESIS OF THE ENANTIOMERS OF CIS-2-METHYL-5-HEXANOLIDE, THE MAJOR COMPONENT OF THE SEX PHEROMONE OF THE CARPENTER BEE

(2R,5S)-2-Methyl-5-hexanolide and its antipode were synthesized in highly optically pure state (98-99percent e.e.) starting from ethyl (S)-lactate and the enantiomers of methyl β-hydroxyisobutyrate.The specific rotations of our samples were D +/- 91.0 -93.5 deg (CHCl3), while the reported values of the samples prepared by resolution or asymmetric synthesis were +/- 64.5-65.6 deg.