96963-50-7

Upstream product

• 134-32-7 1-amino-naphthalene 
• 609-65-4 o-chlorobenzoyl chloride 
• 90-11-9 1-Bromonaphthalene 
• 609-66-5 2-chlorobenzamide 

Downstream Products

• 132141-41-4 5-(2'-Chlorophenyl)-1-(1-naphthyl)tetrazole 
• 218-38-2 benzo[c]phenanthridine 
• 96963-70-1 2-(2-Chloro-phenyl)-naphtho[1,2-d]thiazole 
• 35118-23-1 2-Chloro-N-methyl-N-naphthalen-1-yl-benzamide 
• 96963-39-2 2-Chloro-N-naphthalen-1-yl-thiobenzamide 

Relevant academic research and scientific papers

Synthesis of Aza[ n]phenacenes (n = 4-6) via Photocyclodehydrochlorination of 2-Chloro- N-aryl-1-naphthamides

A novel methodology for the synthesis of aza[n]phenacenes was successfully developed utilizing photocyclodehydrochlorination reaction of 2-chloro-N-aryl-1-naphthamides. In these key intermediates, the factors influencing the photoreaction were studied. The target aza[n]phenacenes were obtained by triflation or chlorination from prepared phenanthridinones, followed by hydrogenation. The introduction of a nitrogen atom into a phenacene skeleton induced changes in the physicochemical properties. The important properties of prepared aza[n]phenacenes (n = 4-6) were studied experimentally and by density functional theory calculations and were compared to those of their carbo analogues. Furthermore, some important features of the crystalline aza[n]phenacenes were investigated, including intermolecular interaction in the crystal lattice and the increased solubility or decreased melting points.

BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS

Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as cyclic GMP-AMP synthase- Stimulator of interferon gene (cGAS-STING) pathway agonists, and useful for treating viral diseases and boost antitumor immunity.

Electrochemical Reactions. Part 23. Intramolecular Radical Substitution during the Reduction of 2-Halogeno-N-methyl-N-naphthylbenzamides

Phenyl radical intermediates formed by the reductive cleavage of the carbon-halogen bond in 2-halogeno-N-methyl-N-(1-naphthyl)benzamides undergo intramolecular substitution to give N-methyl-2-(1-naphthyl)benzamide, and no N-methylbenzophenanthridone is formed.Reduction of 2-halogeno-N-methyl-N-(2-naphthyl)benzamides gives N-methyl-2-(2-naphthyl)benzamide, N-methylbenzophenanthridone, and N-methylbenzophenanthridone.These results complete our comparison of this electrochemical reaction with related radical Pschorr cyclisations.Further reduction of these initial reaction products occurs that only qualitative conclusions can be drawn from the product yields.