96985-63-6Relevant academic research and scientific papers
One-pot synthesis of 1,3,4-oxadiazol-2(3H)-ones with CO2 as a C1 synthon promoted by hypoiodite
Yang, Na,Yuan, Gaoqing
, p. 6639 - 6644 (2019)
A convenient and efficient route has been developed to synthesize 1,3,4-oxadiazol-2(3H)-ones from CO2, hydrazines and aryl or aliphatic aldehydes. Promoted by hypoiodite (IO-) generated in situ from KI and oxidant TBHP, the one-pot synthesis could proceed smoothly to afford the desired products in moderate to high yields. Mechanism studies revealed that nitrile imine was an important intermediate in this transformation. Notably, a commercial herbicide Oxadiazon could be successfully synthesized by this route.
A novel electrochemical conversion of CO2 with aryl hydrazines and paraformaldehyde into 1,3,4-oxadiazol-2(3H)-one derivatives in one step
Yang, Na,Lai, Qiang,Jiang, Huanfeng,Yuan, Gaoqing
, p. 109 - 112 (2016/09/28)
Using CO2 to replace phosgene or CO as the C1 synthon, we successfully achieved the one-pot electrochemical synthesis of 1,3,4-oxadiazol-2(3H)-one derivatives via a three-component coupling reaction of CO2 with aryl hydrazines and pa
