97-37-0Relevant academic research and scientific papers
Copper-catalyzed guanidinylation of aryl iodides: The formation of N,N′-disubstituted guanidines
Cortes-Salva, Michelle,Nguyen, Be-Lan,Cuevas, Javier,Pennypacker, Keith R.,Antilla, Jon C.
supporting information; experimental part, p. 1316 - 1319 (2010/06/15)
Chemical Equation Presented A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N′-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/1 igand system provided a simple diarylation procedure.
