93623-54-2

Upstream product

• 75-15-0 carbon disulfide 
• 95-68-1 2,4-Xylidine 
• 463-71-8 thiophosgene 
• 39842-01-8 2,4-dimethylphenylisothiocyanate 

Downstream Products

• 21789-36-6 2,4-dimethylbenzonitrile 
• 39842-01-8 2,4-dimethylphenylisothiocyanate 
• 97-37-0 N,N'-di-(2,4-dimethyl-phenyl)-guanidine 
• 13278-55-2 N-(2,4-dimethyl-phenyl)-N'-methyl-thiourea 
• 1011794-21-0 3-(2',4'-dimethylphenyl)-2-(2',4'-dimethylphenylimino)-4-methyl-3H-thiazole 
• 1017535-51-1 1-acetyl-1,3-di-(o,p-dimethylphenyl)urea 
• 1158080-98-8 C₁₈H₁₈N₂OS 
• 63520-50-3 1,3-bis(2,4-dimethylphenyl)carbodiimide 
• 1158081-04-9 C₁₈H₂₀N₄O 

Relevant academic research and scientific papers

A facile method for the preparation of carbodiimides from thioureas and (Boc)2O

A concise method for the preparation of carbodiimides from thioureas using di-tert-butyl dicarbonate [(Boc)2O] as the dehydrosulfurizative reagent has been developed. Using DMAP as the catalyst, a variety of symmetric and asymmetric 1,3-diaryl thioureas were converted into the corresponding carbodiimides efficiently in a short time.

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Synthesis and conformational features of sym N,N′,N″- triarylguanidines

A one pot reaction involving sym N,N′-diarylthiourea and the respective arylamine in the presence of aq. KOH in nitrobenzene at ≥105°C afforded sym N,N′,N″-triarylguanidine in fair to good yield and the products have been characterized. Sym N,N′,N″-tri(4-tolyl)guanidine possesses (7) anti-anti conformation, sym N,N′,N″-tri(2-tolyl) guanidine (8) and sym N,N′,N″-tris(2,4-xylyl)guanidine (11) each possess anti-anti αβα conformation whereas sym N,N′,N″-tris(2-anisyl)guanidine possesses (9) syn-anti αββ conformation as determined by single crystal X-ray diffraction data. The observed conformations appear to result from a subtle balance between steric factor associated with the aryl substituent and multiple electronic factors namely n-π conjugation/negative hyperconjugation and non-covalent interactions in the crystal lattice. Indian Academy of Sciences.