97009-67-1

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBONITRILE
• Synonyms: 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBONITRILE;1-(4-Fluorophenyl)cyclopropylnitrile
• CAS NO: 97009-67-1
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.18
• Mol File: 97009-67-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 111.8 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.00755mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBONITRILE(97009-67-1)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-CYCLOPROPANECARBONITRILE(97009-67-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 97009-67-1(Hazardous Substances Data)

Usage

Uses

1-(4-Fluorophenyl)cyclopropanecarbonitrile

InChI:InChI=1/C10H8FN/c11-9-3-1-8(2-4-9)10(7-12)5-6-10/h1-4H,5-6H2

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 96-49-1 [1,3]-dioxolan-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 246180-26-7 1-(cyclopropylidenemethyl)-4-fluorobenzene 
• 106-93-4 ethylene dibromide 

Downstream Products

• 75180-46-0 (1-(4-fluorophenyl)cyclopropyl)methanamine 
• 198976-40-8 (1-(4-fluorophenyl)cyclopropyl)methanol 
• 1262196-94-0 3-[1-(4-fluorophenyl)cyclopropyl]-5-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole 
• 1262194-50-2 5-[1-(4-fluorophenyl)cyclopropyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-methyl-1H-1,2,4-triazole 
• 1253968-50-1 C₁₀H₁₁FN₂*ClH 
• 773100-29-1 1-(4-fluorophenyl)cyclopropane-1-carboxylic acid 
• 133284-48-7 1-(4-fluorophenyl)cyclopropane-1-carboxamide 
• 1021436-45-2 1-(4-fluoro-phenyl)-N-hydroxy-cyclopropanecarboxamidine 

Relevant articles and documents

Nickel-Catalyzed Favorskii-Type Rearrangement of Cyclobutanone Oxime Esters to Cyclopropanecarbonitriles

A nickel-catalyzed base-promoted rearrangement of cyclobutanone oxime esters to cyclopropanecarbonitriles was developed. The ring opening of cyclobutanone oxime esters occurs at the sterically less hindered side. A base-promoted nickelacyclobutane intermediate, formed in situ, is assumed to be involved in the formation of the product.

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. Formula I

Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate

A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.