97027-31-1Relevant articles and documents
Modification of the clozapine structure by parallel synthesis
Su, Jing,Tang, Haiqun,McKittrick, Brian A.,Burnett, Duane A.,Zhang, Hongtao,Smith-Torhan, April,Fawzi, Ahmad,Lachowicz, Jean
, p. 4548 - 4553 (2006)
A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D1-selective and D2-selective compounds can be obtained.