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2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine is a complex organic compound with the molecular formula C18H19ClN4. It is a derivative of dibenzodiazepine, a class of compounds known for their potential therapeutic applications, particularly in the development of drugs for the treatment of various central nervous system disorders. This specific compound features a 2-chloro substitution and a 4-methyl-1-piperazinyl group at the 11-position, which can influence its pharmacological properties. The structure of 2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine allows it to interact with certain receptors in the brain, potentially modulating neurotransmission and exhibiting anxiolytic, sedative, or antipsychotic effects. However, the specific pharmacological profile and therapeutic potential of 2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine would require further investigation through laboratory studies and clinical trials to determine its safety, efficacy, and optimal therapeutic use.

1977-08-8

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1977-08-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1977-08-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1977-08:
(6*1)+(5*9)+(4*7)+(3*7)+(2*0)+(1*8)=108
108 % 10 = 8
So 1977-08-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3

1977-08-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine

1.2 Other means of identification

Product number -
Other names 2-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1977-08-8 SDS

1977-08-8Downstream Products

1977-08-8Relevant academic research and scientific papers

Synthesis and evaluation of antitumor activity of dibenzodiazepine derivatives

Cao, Ke,Yan, Jianwei,Yan, Fulin,Yin, Tiantian

, p. 1111 - 1122 (2020/02/28)

Abstract: A series of dibenzodiazepine 2-position derivatives, bearing N-methylpiperazine at the C-11 position, were prepared by using a concise approach. Their inhibitory activities of tumor cell proliferation in vitro were tested in five cell lines, including breast cancer cell BCAP37, gastric cancer cell SGC7901, liver cancer cell HepG2, cervical cancer cell HeLa and acute promyelocytic leukemia cell HL-60. Several compounds showed efficient tumor activity with IC50 values down to 0.30?μM. These compounds are expected to be a new class of potential anticancer lead compounds. Graphic abstract: [Figure not available: see fulltext.]

Dibenzozepine compound and preparation method and application thereof

-

Paragraph 0150; 0151; 0152; 0166; 0167; 0168, (2018/10/11)

The invention discloses a dibenzozepine compound and a preparation method and application thereof. The structure of the dibenzozepine compound is as shown in the general formula 1 or general formula 2, wherein R1 is selected from methyl, hydrogen, chlorin

Modification of the clozapine structure by parallel synthesis

Su, Jing,Tang, Haiqun,McKittrick, Brian A.,Burnett, Duane A.,Zhang, Hongtao,Smith-Torhan, April,Fawzi, Ahmad,Lachowicz, Jean

, p. 4548 - 4553 (2007/10/03)

A structure-activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D1-selective and D2-selective compounds can be obtained.

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