97041-63-9 Usage
Uses
Used in Pharmaceutical Industry:
6-Bromo-3-methylquinoline is used as a key intermediate in the preparation of Imidazopyrazines, which are adenosine A2A receptor modulators. These modulators have potential therapeutic applications in the treatment of various diseases, including neurological disorders, inflammatory conditions, and certain types of cancer.
In the synthesis of Imidazopyrazines, 6-Bromo-3-methylquinoline plays a crucial role by providing a versatile building block that can be further functionalized and modified to develop new and effective drugs targeting the adenosine A2A receptor. This receptor is known to be involved in various physiological processes, and its modulation can lead to the development of novel therapeutic agents with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 97041-63-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,0,4 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 97041-63:
(7*9)+(6*7)+(5*0)+(4*4)+(3*1)+(2*6)+(1*3)=139
139 % 10 = 9
So 97041-63-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H8BrN/c1-7-4-8-5-9(11)2-3-10(8)12-6-7/h2-6H,1H3
97041-63-9Relevant academic research and scientific papers
Ruthenium-catalysed synthesis of 2- and 3-substituted quinolines from anilines and 1,3-diols
Monrad, Rune Nygaard,Madsen, Robert
body text, p. 610 - 615 (2011/02/28)
A straightforward synthesis of substituted quinolines is described by cyclocondensation of anilines with 1,3-diols. The reaction proceeds in mesitylene solution with catalytic amounts of RuCl3·xH 2O, PBu3 and MgBr2·OEt2. The transformation does not require any stoichiometric additives and only produces water and dihydrogen as byproducts. Anilines containing methyl, methoxy and chloro substituents as well as naphthylamines were shown to participate in the heterocyclisation. In the 1,3-diol a substituent was allowed in the 1- or the 2-position giving rise to 2- and 3-substituted quinolines, respectively. The best results were obtained with 2-alkyl substituted 1,3-diols to afford 3-alkylquinolines. The mechanism is believed to involve dehydrogenation of the 1,3-diol to the 3-hydroxyaldehyde which eliminates water to the corresponding α,β-unsaturated aldehyde. The latter then reacts with anilines in a similar fashion as observed in the Doebner-von Miller quinoline synthesis.
