97059-86-4

Upstream product

• 100-52-7 benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 1889-84-5 4'-methoxybenzoin 
• 1147550-11-5 ammonium thiocyanate 
• 17356-08-0 thiourea 

Downstream Products

• 62894-62-6 5-(4-Methoxy-phenyl)-4-phenyl-2-(1,1,2,2-tetrafluoro-ethylsulfanyl)-1H-imidazole 
• 873427-34-0 2-ethylsulfanyl-4-(4-methoxy-phenyl)-5-phenyl-1H-imidazole 
• 116930-73-5 [4-(4-Methoxy-phenyl)-5-phenyl-1H-imidazol-2-ylsulfanyl]-acetic acid hydrazide 
• 97059-92-2 5-(4-Methoxy-phenyl)-2-methylsulfanyl-4-phenyl-1H-imidazole 

Relevant academic research and scientific papers

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.

SYNTHESIS AND REACTIONS OF 4,5-DIARYL-2-MERCAPTOIMIDAZOLES

4,5-Diaryl-2-mercaptoimidazoles (II) were synthesized and reacted with chloroacetic acid to form the S-carboxymethyl derivatives (III).The latter compounds were readily cyclised into the corresponding 5,6-diaryl-2,3-dihydroimidazo(2,1-b) thiazol-3-ones (I