97077-45-7Relevant academic research and scientific papers
Three-component Friedel-Crafts reaction of indoles, glyoxylate, and amine under solvent-free and catalyst-free conditions - Synthesis of (3-indolyl)glycine derivatives
Zhao, Jun-Ling,Liu, Li,Zhang, Hai-Bo,Wu, Yan-Chao,Wang, Dong,Chen, Yong-Jun
, p. 96 - 100 (2006)
Solvent-free and catalyst-free three-component reactions of indoles, amines, and ethyl glyoxylate gave alkylation products in good to high yields (61-93%), providing a convenient synthesis of (3-indolyl)glycine derivatives. Georg Thieme Verlag Stuttgart.
Synthesis of α-(3-indolyl)glycine derivatives via spontaneous Friedel-Crafts reaction between indoles and glyoxylate imines
Jiang, Biao,Huang, Zuo-Gang
, p. 2198 - 2204 (2007/10/03)
Mannich-type Friedel-Crafts reaction between indoles and ethyl glyoxylate imines proceeded spontaneously in the absence of an acid catalyst. Ethyl α-(3-indolyl)glycinates were obtained in moderate to high yields. Reaction with (R)-α-methylbenzylamine deri
Ytterbium triflate catalyzed electrophilic substitution of indoles: The synthesis of unnatural tryptophan derivatives
Janczuk, Adam,Zhang, Wei,Xie, Wenhua,Lou, Sanzhong,Cheng, JinPei,Wang, Peng G.
, p. 4271 - 4274 (2007/10/03)
Benzylamine was combined with ethyl glyoxylate to form the intermediate imine which in the presence of catalytic amount of Yb(OTf)3 underwent electrophilic substitution on the 3-position of a variety of indoles to produce unnatural tryptophan d
