Three-component Friedel-Crafts reaction of indoles, glyoxylate, and amine under solvent-free and catalyst-free conditions - Synthesis of (3-indolyl)glycine derivatives

Article abstract of DOI:10.1055/s-2005-922764

Solvent-free and catalyst-free three-component reactions of indoles, amines, and ethyl glyoxylate gave alkylation products in good to high yields (61-93%), providing a convenient synthesis of (3-indolyl)glycine derivatives. Georg Thieme Verlag Stuttgart.