971-86-8

Upstream product

• 613-90-1 benzoyl cyanide 
• 100-66-3 methoxybenzene 
• 100-58-3 phenylmagnesium bromide 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 103791-08-8 4-(phenylmethoxy)diphenylmethanol 
• 39696-82-7 2-(4-hydroxyphenyl)-2-phenylacetonitrile 
• 108-95-2 phenol 
• 71-43-2 benzene 
• 861342-93-0 bis-(4-benzoyloxy-phenyl)-phenyl-acetic acid amide 
• 120264-80-4 2,2-bis(4-methoxyphenyl)-2-phenylacetonitrile 
• 664-35-7 Hydroxy-phenyl-bis-(4-hydroxy-phenyl)-methan 
• 151-50-8 potassium cyanide 

Downstream Products

• 861342-93-0 bis-(4-benzoyloxy-phenyl)-phenyl-acetic acid amide 

Relevant academic research and scientific papers

δ-Cyano substituted: Para -quinone methides enable access to unsymmetric tri- And tetraarylmethanes containing all-carbon quaternary stereocenters

para-Quinone methides bearing an electron-withdrawing cyano group at the exocyclic methylene δ-position were identified as valuable 1,6-conjugate addition building blocks for acyclic all-carbon quaternary stereocenter construction. A wide variety of electron-rich arenes as nucleophiles were tolerated, effectively furnishing diverse unsymmetrical triarylmethanes bearing all-carbon quaternary stereocenters. The robust transformable abilities of the cyano group provide a platform to access other valuable functional group-containing unsymmetrical tri- and tetraarylmethanes that are otherwise difficult to be prepared. Computational studies supported the hypothesis that the cyano group at the δ-position tunes the molecular electron-density distribution, and the stability of para-quinone methides is enhanced by lowering their polymerizability.