97110-83-3Relevant academic research and scientific papers
Robust synthesis of N-sulfonylazetidine building blocks via ring contraction of α-bromo N-sulfonylpyrrolidinones
Kern, Nicolas,Felten, Anne-Sophie,Weibel, Jean-Marc,Pale, Patrick,Blanc, Aurlien
, p. 6104 - 6107 (2014)
A simple and robust one-pot nucleophilic addition-ring contraction of α-bromo N-sulfonylpyrrolidinones has been achieved toward α-carbonylated N-sulfonylazetidines. In the presence of potassium carbonate, various nucleophiles, such as alcohols, phenols or anilines, have been efficiently incorporated into the azetidine derivatives. Moreover, the α-bromopyrrolidinone precursors could be selectively obtained in good yields by monobromination of cheap and easily available N-sulfonyl-2-pyrrolidinone derivatives.
Catalytic and enantioselective diels-alder reaction of silyloxydiene that incorporates a pyrrolidine ring, and its application to the construction of chiral triand tetracyclic skeletons
Harada, Shinji,Nakashima, Saki,Yamada, Wataru,Morikawa, Takahiro,Nishida, Atsushi
, p. 872 - 893 (2017/07/27)
The enantioselective Diels-Alder reaction of silyloxydiene that incorporates a pyrrolidine ring was studied. This reaction was catalyzed by a chiral holmium complex and gave multi-substituted chiral hydroindoles that contained a silyl enol ether, which is a key functional group for further transformations. We demonstrate here the synthesis of chiral pyrroloacridine, dibenzodiazocine, and pyrrolocarbazole skeletons.
Biomimetic aerobic oxidation of amino alcohols to lactams
Babu, Beneesh P.,Endo, Yoshinori,Baeckvall, Jan-E.
supporting information, p. 11524 - 11527,4 (2012/12/11)
The right path: N-Protected amino alcohols undergo aerobic and biomimetic oxidation to the corresponding lactams in the presence of a ruthenium catalyst and a combination of electron-transfer mediators under air (see scheme). The reaction was used for the synthesis of five-, six-, and seven-, membered lactams and showed good tolerance to a number of N-protecting groups. Copyright
A convenient synthesis of p-substituted 1-arylsulfonyl-pyrrolidin-2-ones
Zareef, Muhammad,Iqbal, Rashid,Khan, Khalid M.,Zaidi, Javid H.,Zia-Ullah,Arfan, Muhammad
experimental part, p. 485 - 488 (2010/06/19)
A convenient and novel method of cyclisation of 4-(4-substituted- phenylsulfonamido)-butanoic acids to their corresponding p-substituted 1-arylsulfonyl-pyrrolidin-2-ones was achieved by using polyphosphate ester (PPE). The reaction times were considerably
