97113-36-5

Upstream product

• 103-89-9 4-Methylacetanilide 
• 7745-92-8 2-iodo-1-methyl-4-nitrobenzene 
• 35944-64-0 3-iodo-4-methylaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 876494-97-2 2-bromo-5-iodo-4-methyl-aniline 
• 73655-51-3 4-amino-2-iodobenzoic acid 
• 97112-71-5 4-Methyl-2-nitro-5-piperidin-1-yl-benzonitrile 
• 97112-84-0 2-Amino-4-methyl-5-piperidin-1-yl-benzonitrile 
• 97112-59-9 5-iodo-4-methyl-2-nitrobenzonitrile 
• 97113-38-7 5-iodo-4-methyl-2-nitroaniline 
• 97113-37-6 5-iodo-4-methyl-2-nitroacetanilide 
• 126116-23-2 4-acetamido-2-iodobenzoic acid 
• 860741-04-4 acetic acid-(2-bromo-5-iodo-4-methyl-anilide) 

Relevant academic research and scientific papers

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

Palladium/carbon catalytic aromatic functional group on the adjacent position iodizate method

The invention discloses a method for iodization of an ortho-position of a functional group on a palladium/carbon catalytic aromatic ring. The method comprises the following steps: mixing an aromatic ring of which a substrate contains a functional group, a