97152-19-7

Upstream product

• 186581-53-3 diazomethane 
• 97152-40-4 2,2',3,3',4,4'-hexakis(benzyloxy)-1,1'-biphenyl-6,6'-dicarboxylic acid 
• 1123215-07-5 methyl 3,5-bis(benzyloxy)-4-hydroxybenzoate 
• 675616-37-2 methyl 3,4,5-tris(benzyloxy)-2-bromobenzoate 
• 70424-94-1 methyl 3,4,5-tris(benzyloxy)benzoate 
• 100-39-0 benzyl bromide 
• 99-24-1 methyl galloate 
• 154675-20-4 dibenzyl 2,2',3,3',4,4'-hexabenzyloxybiphenyl-6,6'-dicarboxylate 
• 915215-48-4 2,2'-dihydroxy-3,3,',4,4'-tetrakis(benzyloxy)-1,1'-biphenyl-6,6'-dicarboxylic acid 
• 67-56-1 methanol 
• 23094-69-1 corilagin 
• 476-66-4 ellagic acid 
• 100-44-7 benzyl chloride 
• 103442-14-4 tetrabenzylellagic acid 

Downstream Products

• 911701-75-2 (R)-3,3'-dibromo-4,5,6,4',5',6'-hexabenzyloxydiphenate dimethyl ester 
• 911701-75-2 (S)-3,3'-dibromo-4,5,6,4',5',6'-hexabenzyloxydiphenate dimethyl ester 
• 476-66-4 ellagic acid 

Relevant academic research and scientific papers

Preparation of isodehydrodigallic acid using Ullmann condensation

Isodehydrodigallic acid, which is an important component of several ellagitannin compounds, was easily synthesized using a classical Ullmann condensation reaction.

Synthetic Ellagic Acid Glycosides Inhibit Early Stage Adhesion of Streptococcus agalactiae Biofilms as Observed by Scanning Electron Microscopy

Ellagic acid derivatives possess antimicrobial and antibiofilm properties across a wide-range of microbial pathogens. Due to their poor solubility and ambident reactivity it is challenging to synthesize, purify, and characterize the activity of ellagic acid glycosides. In this study, we have synthesized three ellagic acid glycoconjugates and evaluated their antimicrobial and antibiofilm activity in Streptococcus agalactiae (Group B Streptococcus, GBS). Their significant impacts on biofilm formation were examined via SEM to reveal early-stage inhibition of cellular adhesion. Additionally, the synthetic glycosides were evaluated against five of the six ESKAPE pathogens and two fungal pathogens. These studies reveal that the ellagic acid glycosides possess inhibitory effects on the growth of gram-negative pathogens.

OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME

The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C

We have previously shown that some ellagitannins are potent inhibitors of protein kinase C (PKC). On the basis of this finding, several series of hexahydroxybiphenyl derivatives of ellagic acid were synthesized as simple analogs of these ellagitannins and were evaluated for their inhibitory effect against PKC. Compounds 23 and 26 were found to be potent inhibitors of PKC, while hexakis(benzyloxy)biphenyl derivatives exhibited weak anti-PKC activity.