97184-71-9Relevant academic research and scientific papers
Transformations of 2-alkoxy-6-chloro- and 6-alkoxy-2-chloro-7-methylpurines under the action of methyl iodide
Kowalska,Maslankiewicz
, p. 1327 - 1331 (2007/10/03)
2-Alkoxy-6-chloro-7-methylpurines 3 were prepared by 6-chloro-dealkoxylation of 2,6-dialkoxy-7-methylpurines 4. Reactions of alkoxy-chloro-7-methylpurines 2 and 3 with methyl iodide led as N-9 methylation and as N-3 methylation to give N-methyl purinium salts 9 and 11 from purine 2 or 6 and 7 from purine 3. The formation of purinium salts was accompanied by 6-iodo-dechlorination leading from 3 to 6-iodopurinium salt 5 and by alkyl iodide elimination leading to hypoxanthine 10.
2,6-Dialkoxy-7-methylpurines
Kowalska, Alicja,Maslankiewicz, Andrzej,Syrek, Barbara,Cieplinski, Piotr
, p. 341 - 352 (2007/10/02)
The preparation of unsymmetrical 2,6-dialkoxy-7-methylpurines (2), and 2-alkoxy-1,7-dialkyl-6-oxo-1,6-dihydropurines (5) is described.In contrast to 1 and 2, a facile thermal lactim-lactam rearrangement from hypoxanthines 5 and 7 into xanthines 6 was observed. - Keywords: Nucleophilic heteroaromatic substitution; thermal lactim-lactam rearrangement; Sigmatropic shifts; Dialkoxy-7H-purines; Dialkyl-1H(or 3H),7H-hypoxanthines; Trialkyl-7H-xanthines
