97205-34-0

Usage

Uses

Used in Pharmaceutical Industry:
Nebracetam is used as a cognitive enhancer for improving memory, learning, and cognitive function. Its mechanism of action involves influencing the neurotransmitter acetylcholine, which plays a crucial role in memory and learning processes.
Used in Neurodegenerative Disease Treatment:
Nebracetam is used as a potential therapeutic agent for treating neurodegenerative diseases and cognitive impairments. Its cognitive enhancing properties may help alleviate symptoms and improve the quality of life for patients suffering from such conditions.

InChI:InChI=1/2C12H16N2O.C4H4O4/c2*13-7-11-6-12(15)14(9-11)8-10-4-2-1-3-5-10;5-3(6)1-2-4(7)8/h2*1-5,11H,6-9,13H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+

Upstream product

• 64-17-5 ethanol 
• 110-17-8 (2E)-but-2-enedioic acid 
• 617-52-7 Dimethyl itakonate 
• 100-46-9 benzylamine 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 
• 1373821-40-9 C₁₃H₁₇NO₄S 

Downstream Products

• 676627-00-2 5-aminomethylpyrrolidin-2-one 
• 103296-07-7 4-(p-chlorophenylamino-carbonylaminomethyl)-1-benzylpyrrolidin-2-one 
• 676630-95-8 N-(5-oxo-pyrrolidin-3-ylmethyl)-6-(2,4-dichloro-phenylamino)-4-trifluoromethyl-nicotinamide 
• 156640-14-1 1-benzyl-4-(4-(2,3'-dichlorobenzhydryl)piperazin-1-ylcarbonylaminomethyl)-2-oxopyrrolidine 

Relevant academic research and scientific papers

A method for preparing west Naira Tanzania

The invention discloses a preparation method for nebracetam, and belongs to the technical field of medical chemistry. The key points of the technical scheme of the invention are as follows: the preparation method for the nebracetam comprises the following steps: performing Michael addition reaction and intramolecular cyclization on dimethyl itaconate and benzylamine serving as raw materials to obtain 1-benzyl-5-oxopyrrolidin-3-carboxylic methyl ester; reducing the 1-benzyl-5-oxopyrrolidin-3-carboxylic methyl ester by sodium borohydride to obtain 1-benzyl-4-hydroxymethyl-pyrrolidine-2-keton; performing methyl sulfonylation on the 1-benzyl-4-hydroxymethyl-pyrrolidine-2-keton to obtain 1-benzyl-5-oxopyrrolidin-3-carboxylic methanesulfonate; finally, performing ammonification and reduction on the 1-benzyl-5-oxopyrrolidin-3-carboxylic methanesulfonate by using ammonia water to obtain the nebracetam. The preparation method is simple in preparation process, easy to control and high in target product yield, and meets the requirement for green chemistry.

Agent with an antidepressant activity

An improved process for employing tricyclic antidepressants involving co-administration of a N-benzyl-pyrrolidin-2-one.

Agent with an antidepressant activity

An improved process for employing tricyclic antidepressants involving co-administration of a N-benzyl-pyrrolidin-2-one.

Use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants

The invention relates to the use of 1-benzyl-aminoalkyl-pyrrolidinones as antidepressants.

Piperazinyl and morpholinyl substituted 1-(benzyl or pyridylmethyl)-4-or-5-aminomethyl-pyrrolidin-2-ones and their nootropic use

Compounds of the formula STR1 wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms; R2 is 2-, 3- or 4-pyridyl, phenyl or mono- or di- substituted phenyl, where the substituents are each individually alkoxy of 1 to 2 carbon atoms, f