97295-30-2Relevant academic research and scientific papers
REACTION OF 2,2-DICHLOROACETOPHENONE AND BENZALDEHYDES UNDER CONDITIONS OF THE DARZENS CONDENSATION
Mamedov, V. A.,Polushina, V. L.,Mertsalova, F. F.,Nuretdinov, I. A.
, p. 170 - 171 (1992)
The reaction of 2,2-dichloroacetophenone with benzaldehydes was studied under Darzens condensation conditions.Benzaldehyde, p-bromobenzaldehyde, and o,p-dichlorobenzaldehyde condensed with 2,2-dichloroacetophenone to give 1-phenyl-3-aryl-3-chloro-1,2-prop
Highly diastereo- and enantioselective organocatalytic domino michael/aldol reaction of acyclic 3-halogeno-1,2-diones to α,β-unsaturated aldehydes
Lefranc, Alice,Guenee, Laure,Alexakis, Alexandre
supporting information, p. 2172 - 2175 (2013/06/05)
The first organocatalytic diastereo- and enantioselective domino Michael/aldol reaction of 3-halogeno-1,2-diones to α,β-unsaturated aldehydes has been achieved. This transformation tolerates a large variety of electronically different substituents on both reactive partners and allows the synthesis of challenging cyclopentanone derivatives with four contiguous stereogenic centers in excellent diastereoselectivities (>20:1 dr) as well as good yields (69-97%), and enantioselectivities (up to 94% ee).
Darzens Reaction as a Convenient Method for the Synthesis of α-Chloroketones, α-Chloroepoxides, and Symmetrically Substituted Dioxines
Mamedov, V. A.,Litvinov, I. A.,Kataeva, O. N.,Rizvanov, I. Kh.,Nuretdinov, I. A.
, p. 1427 - 1436 (2007/10/02)
The Darzens reaction of dichloroacetophenone (DCAP) with substituted benzaldehydes has been studied.The structure of the products was shown to depend on the phenyl group substituents.Reaction of benzaldehyde, 4-bromo-, and 2,4-dichlorobenzaldehydes result
Reactions of Carbanions with Carbon Tetrachloride in Two-Phase Systems. Chlorinated Products as Nucleophilic and Electrophilic Intermediates
Makosza, M.,Kwast, A.,Kwast, E.,Jonczyk, A.
, p. 3722 - 3727 (2007/10/02)
A variety of carbanions generated in the catalytic two-phase system (aqueous NaOH or K2CO3 and tetrabutylammonium bromide catalyst) react with CCl4 to form chlorinated products that can react as nucleophiles and electrophiles.Thus, chlorinated intermediates generated from arylacetonitriles and propiophenone in the presence of aldehydes and electrophilic alkenes form oxirane and cyclopropane derivatives, respectively.The chlorinated intermediates act as electrophiles toward Cl3C- giving (trichloromethyl)oxiranes (from aryl alkyl ketones), α-trichloromethyl nitriles (from phenyl(dialkylamino)acetonitriles), and benzoyldichloro enamines (from α-dialkylamino ketones).From secondary nitroalkanes both chloronitroalkanes and dinitro compounds can be produced.
