97304-17-1

Basic information

• Product Name: 1-(2,4-dihydroxy-5-pentyl-phenyl)-ethanone
• Synonyms: 1-(2,4-dihydroxy-5-pentyl-phenyl)-ethanone
• CAS NO: 97304-17-1
• Molecular Weight: 222.284
• Mol File: 97304-17-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2,4-dihydroxy-5-pentyl-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dihydroxy-5-pentyl-phenyl)-ethanone(97304-17-1)
• EPA Substance Registry System: 1-(2,4-dihydroxy-5-pentyl-phenyl)-ethanone(97304-17-1)

Safety Data

• Hazardous Substances Data: 97304-17-1(Hazardous Substances Data)

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 59968-09-1 2,4-dimethoxy-1-pentylbenzene 
• 638-29-9 n-valeryl chloride 
• 854659-33-9 1-(2,4-dimethoxyphenyl)pentan-1-one 
• 108-46-3 recorcinol 
• 15116-13-9 1-(2,4-dihydroxyphenyl) pentan-1-one 
• 533-24-4 4-pentyl resorcinol 
• 75-36-5 acetyl chloride 
• 117690-84-3 5-Pentyl-2,4-dimethoxyacetophenone 
• 75-05-8 acetonitrile 

Downstream Products

• 117690-70-7 5-(4-Acetyl-5-hydroxy-2-pentylphenoxy)-pentanenitrile 

Relevant articles and documents

Leukotriene B4 Receptor Antagonists: The LY255283 Series of Hydroxyacetophenones

A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-oxy>phenyl>ethanone (compound 35, LY255283).Using an assay for inhibition of specific LTB4 binding to human PMN, we found that substitution of a nonpolar substituent in the 5-position was required for activity.Best activity was realized with hydrogen in the 3-position, hydroxyl in the 2-position, short chain alkyl ketone in the 1-position, and a six- or eight-carbon chain linking the oxygen in the 4-position with an unsaturated terminal function.Compound 35, having an IC50 of 87 nM in the binding assay, was chosen for further preclinical evaluation.

Antifungal Activity of 2,4-Dihydroxyacylophenones and Related Compounds

The antifungal activity of 2,4-dihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to determine their structure-activity relationships.The activity of these compounds was found to be closely related to the length of the acyl and alkyl substituents attached to the 1,3-dihydroxybenzene moiety.In addition, differences in activity were observed depending on the position of the alkyl substituents and on the number of substituents attached to the 1,3-dihydroxybenzene moiety.Some compounds tested showed potent antifungal activity against Trichophyton spp. and other fungi that was more active than amphotericin B.