97311-78-9Relevant academic research and scientific papers
Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)-H Bonds
Miao, Jinmin,Yang, Ke,Kurek, Martin,Ge, Haibo
supporting information, p. 3738 - 3741 (2015/08/18)
The transition-metal-catalyzed direct C-H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C-H functionalization, site-selective fluorination of unactivated sp3 carbons remains a challenge. Direct, highly site-selective and diastereoselective fluorination of aliphatic amides via a palladium-catalyzed bidentate ligand-directed C-H bond functionalization process on unactivated sp3 carbons is reported. With this approach, a wide variety of β-fluorinated amino acid derivatives and aliphatic amides, important motifs in medicinal and agricultural chemistry, were prepared with palladium acetate as the catalyst and Selectfluor as the fluorine source.
On the cis-Effect of Radical Addition Reactions at Alkenes
Giese, Bernd,Lachhein, Stephen
, p. 1616 - 1620 (2007/10/02)
The trans-alkenes 2e - h react faster with cyclohexyl radicals than the cis-alkenes 3e - h (Table 1).Radical addition reactions at alkylidenemalonic esters 1 show that this cis-effect increases with the bulkyness of the substituents (Table 1).However, the difference in the reactivity between trans- and cis-alkenes exerts no effect on the regioselectivity (Table 3).It is concluded that the reason for the cis-effect is a twisting of the ?-system that influences the reactivity of both vinylic C-atoms to the same extent.
