97326-08-4

Upstream product

• 67-56-1 methanol 
• 97326-01-7 (1S,8aR)-1-Chloro-8a-(3,4-dimethoxy-phenyl)-5,6-dimethoxy-1,8a-dihydro-3H-8-thia-2a-aza-cyclobuta[b]naphthalen-2-one 
• 124-41-4 sodium methylate 
• 65448-21-7 6,7-dimethoxy-2-(3',4'-methylenedioxyphenyl)-4H-1,3-benzothiazine 

Downstream Products

• 110694-91-2 4-carbomethoxy-6,7-dimethoxy-3-(3',4'-dimethoxyphenyl)-isoquinoline 

Relevant academic research and scientific papers

Ring transformations of β-lactam-condensed 1,3-benzothiazines to isoquinoline and thiazole derivatives by sulfur extrusion and addition sequences

The ring transformations of dichloro-β-lactam-fused 2-aryl-1,3-benzothiazines with sodium methoxide were investigated. With 2 equiv of base, the dichloro-β-lactam derivatives underwent rearrangement and dihydro-1,4-benzothiazepines, 3,4-substituted isoquinolines and substituted thiazole disulfides were isolated. A possible reaction mechanism is proposed for the simultaneous formation of the novel products. The formation of isoquinoline and thiazole derivatives can be explained by sulfur extrusion and addition sequences.