97347-31-4

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 657-27-2 L-Lysine hydrochloride 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 

Downstream Products

• 97347-44-9 (R)-6-Oxo-2,6-bis-(2,2,2-trichloro-ethoxycarbonylamino)-hexanoic acid 4-nitro-benzyl ester 
• 97347-44-9 N^α,N^ca-diTroc-L-2-aminoadipamic acid p-nitrobenzyl ester 

Relevant academic research and scientific papers

Chemical Conversion of L-α,ο-Diamino Acids to L-ο-Carbamoyl-α-amino Acids by Ruthenium tetroxide Oxidation

Ruthenium tetroxide oxidation of N,C-protected derivatives of L-2,4-diaminobutyric acid, L-ornitine and L-lisine was carried out two-phase conditions and the corresponding imides, formed through the oxidation of the methylene adjacent to the ο-amino group, were obtained in good yields.Removal of the protecting groups from the products gave L-asparagine, L-glutamine and L-2-aminoadipic acid 6-amide, respectively.Thus the first chemical conversion of L-α,ο-diamino acids into the corresponding L-ο-carbamoyl-α-amino acids without racemization has been established.L-2-Aminoadipic acid 6-amide was further converted to L-2-aminoadipic acid by acid hydrolysis.This represents a convenient method for the synthesis of L-2-aminoadipic acid starting from L-lisine.Keywords - oxidation; ruthenium tetroxide; L-α-amino acid synthesis; N-protecting group; ruthenium tetroxide; L-α,ο-diamino acid; L-ο-carbamoiyl-α-amino acid; L-2-aminoadipicacid