97379-32-3

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 637-87-6 1-Chloro-4-iodobenzene 
• 108-90-7 chlorobenzene 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 134-85-0 4-chlorobenzophenone 

Downstream Products

• 192642-27-6 1-((E)-3-Bromo-1-phenyl-propenyl)-4-chloro-benzene 
• 701194-98-1 1-(4-chlorophenyl)-3-phenyl-2-propen-1-amine 
• 121597-97-5 N-<3-(4-chlorophenyl)-3-phenyl-2-propen-1-yl>phthalimide 

Relevant academic research and scientific papers

Friedel-Crafts alkenylation of arenes using alkynes catalysed by metal trifluoromethanesulfonates

Metal trifluoromethanesulfonates [M(OTf)(n); M = Sc, Zr, In] catalyse the Friedel-Crafts alkenylation of arenes using alkynes, including internal alkynes, to give, through an alkenyl cation intermediate, 1,1-diarylalkenes in high to excellent yields.

Copper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins

The copper-catalyzed hydroarylation of internal, unsymmeric alkynes is presented. Trisubstituted alkenes are obtained as single diastereomers in good to excellent yields and excellent regioselectivities. The scope of the reaction is presented with respect to alkyne and aryl iodide coupling partners. Initial mechanistic experiments indicate a hydrocupration event followed by a two-electron oxidative addition/reductive elimination pathway.

Synthesis and in Vitro Pharmacology of Arpromidine and Related Phenyl(pyridylalkyl)guanidines, a Potential New Class of Positive Inotropic Drugs

Replacement of the cimetidine moiety in impromidine (1, N1--N2-thio>ethyl>guanidine) by more lipophilic H2-nonspecific pheniramine-like structures resulted