97419-60-8

Upstream product

• 82017-87-6 chloro-2, N,N' diphenyl-1,3 diazaphospholane-1,3,2 
• 109-89-7 diethylamine 
• 150-61-8 N,N'-diphenylethylenediamine 

Downstream Products

• 97419-61-9 3-endo-benzoyloxy-2-exo-(1,3-diphenyl-1,3,2-diazaphospholan-2-yloxymethyl)-6-oxobicyclo<3.3.0>octane 
• 22398-80-7 indium phosphide 
• 97419-66-4 3-endo-benzoyloxy-2-exo-(1,3-diphenyl-1,3,2-diazaphospholan-2-yloxymethyl)-7-oxobicyclo<3.3.0>octane 

Relevant academic research and scientific papers

Mitsunobu Reaction Using Basic Amines as Pronucleophiles

A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleophiles to form C-N bonds through the utilization of N-heterocyclic phosphine-butane (NHP-butane) has been developed. Both aliphatic alcohols and benzyl alcohols are suitable substrates for C-N bond construction. Various acidic nucleophiles such as benzoic acids, phenols, thiophenol, and secondary sulfonamide also provide the desired products of esters, ethers, thioether, and tertiary sulfonamide with 43-93% yields. Importantly, C-N bond-containing pharmaceuticals, Piribedil and Cinnarizine, have been synthesized in one step from the commercial amines under this Mitsunobu reaction system.