97457-07-3Relevant academic research and scientific papers
Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties
Byamukama, Robert,Kamau, Rahab W.,Kumarihamy, Mallika,Masila, Veronica M.,Midiwo, Jacob O.,Muhammad, Ilias,Ndakala, Albert J.
, (2020/10/27)
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of 50 value of 14.97μg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-microbial and anti-fungal activities.
13C NMR substituent chemical shifts in hydroxy-p-benzoquinones
Burgueno-Tapia, Eleuterio,Joseph-Nathan, Pedro
, p. 390 - 393 (2007/10/03)
Substituent chemical shift (scs) values for the acetylation and mesylation of hydroxy-p-benzoquinones and for the introduction of acetyloxy and mesyloxy groups into p-benzoquinones were derived after complete 13C NMR assignment of all ring carbons for nine perezone derivatives and six thymoquinone derivatives, which follow from one-bond and long-range multiplicities. Copyright
CUAUTHEMONE SESQUITERPENOIDS FROM BLUMEA ALATA
Bohlmann, Ferdinand,Wallmeyer, Michael,Jakupovic, Jasmin,Gerke, Thomas,King, Robert M.,Robinson, Harold
, p. 505 - 510 (2007/10/02)
Key Word Index - Blumea spp.; Pterocaulon virgatum; Compositae; Inuleae; sesquiterpenes; cuauthemone derivatives; thymol derivatives; himachalane derivatives; eremophilane derivative. The investigation of five Blumea species afforded, in addition to known compounds, several cuauthemone derivatives, most of them being 7,11-epoxides, some thymol derivatives, an eremophilane epoxide and a himachalane diol.From Pterocaulon virgatum a further himachalane derivative wasisolated.The structures were elucidated by spectroscopic methods and in part by partial synthesis.
