97475-97-3Relevant academic research and scientific papers
Flow microwave technology and microreactors in synthesis
Baxendale, Ian R.,Hornung, Christian,Ley, Steven V.,De Mata Munoz Molina, Juan,Wikstroem, Anders
, p. 131 - 144 (2013/03/28)
A bespoke microwave reactor with a glass containment cell has been developed for performing continuous flow reactions under microwave heating. The prototype unit has been evaluated using a series of standard organic chemical transformations enabling scale-up of these chemical processes. As part of the development, a carbon-doped PTFE reactor insert was utilized to allow the heating of poorly absorbing reaction media, increasing the range of solvents and scope of reactions that can be performed in the device.
PROCESS FOR THE PREPARATION OF 2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID DERIVATIVES
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Page/Page column 17, (2008/06/13)
The present invention is aimed at a process for the preparation of compounds of the general formula (I) through the hydrogeneration of cyclization of the intermediates of the formula (II)
EINE EINFACHE DIASTEREOSELEKTIVE SYNTHESE VON (1SR,3SR,5SR)-2-AZABICYCLOOCTAN-3-CARBONSAEURE
Urbach, H.,Henning, R.
, p. 1839 - 1842 (2007/10/02)
(1SR,3SR,5SR)-2-Azabicyclooctane-3-carboxylic acid, precursor of the angiotensin-converting-enzyme-inhibitor Hoe 498, is easily prepared from 1-chloro-1-cyclopentene-2-carbaldehyde in three steps.
